My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.