1. < Neuropathy

Anyone Heard of Pirenzepine for Small Fiber Neuropathy?

Posted by cwallen9 @cwallen9, Jan 28, 2019

I just read articles about a drug called Pirenzepine that is being studied to help heal nerve damage. It is being touted as a cure for small fiber neuropathy. I think it is still in the study phase, but is used for other things such as stomach ulcers.

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jeffrapp | @jeffrapp | Feb 18, 2021
In reply to @windsorchris "Not yet, but doing research on just where I can purchase and eager to talk to..." + (show)
@windsorchris

Not yet, but doing research on just where I can purchase and eager to talk to others who have found and applied pirenzepine.

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I believe it is available from the company on a compassionate use basis. If so, your MD will have to fill out a form. Contact the company mentioned above to get info.
If you do use it, please let us know how well (or not) it works.

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1 reply
windsorchris | @windsorchris | Mar 9, 2021

Noticed there were many reports from people who were going to compound their own pirenzepine (phase 2 trials - regenerates peripheral nerves) but no follow-up comments. Is there anyone out there who can add to this discussion?

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2 replies
sport1776 | @sport1776 | Mar 9, 2021
In reply to @windsorchris "Noticed there were many reports from people who were going to compound their own pirenzepine (phase..." + (show)
@windsorchris

Noticed there were many reports from people who were going to compound their own pirenzepine (phase 2 trials - regenerates peripheral nerves) but no follow-up comments. Is there anyone out there who can add to this discussion?

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Is there a way I can get in this clinical trial? I have had peripheral neuropathy for 15 plus years? Thank you.

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Mentor
John, Volunteer Mentor | @johnbishop | Mar 9, 2021
In reply to @windsorchris "Noticed there were many reports from people who were going to compound their own pirenzepine (phase..." + (show)
@windsorchris

Noticed there were many reports from people who were going to compound their own pirenzepine (phase 2 trials - regenerates peripheral nerves) but no follow-up comments. Is there anyone out there who can add to this discussion?

Jump to this post

Here's a page that shows the clinical trials. You will need to check with the contacts listed - https://clinicaltrials.gov/ct2/show/NCT04786340

REPLY
windsorchris | @windsorchris | Jul 4, 2021
In reply to @jeffrapp "I believe it is available from the company on a compassionate use basis. If so, your..." + (show)
@jeffrapp

I believe it is available from the company on a compassionate use basis. If so, your MD will have to fill out a form. Contact the company mentioned above to get info.
If you do use it, please let us know how well (or not) it works.

Jump to this post

Are you aware of any published "results" or summary of clinical trials for pirenzepine known? I find abstracts on proposed trials but no summary.

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1 reply
jeffrapp | @jeffrapp | Jul 5, 2021
In reply to @windsorchris "Are you aware of any published "results" or summary of clinical trials for pirenzepine known? I..." + (show)
@windsorchris

Are you aware of any published "results" or summary of clinical trials for pirenzepine known? I find abstracts on proposed trials but no summary.

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Here's one:
https://jpet.aspetjournals.org/content/374/1/44

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janstar61 | @janstar61 | Jul 6, 2021

I actually contacted the owner of the company that was to be testing that drug. I am not sure they were able to get the funds to complete the studies. My doctor said he has not heard of anything that cures neuropathy as of yet.

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1 reply
ubikings | @ubikings | Jan 4, 2022

Let's hope the needful is done soonest

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1 reply
Mentor
John, Volunteer Mentor | @johnbishop | Jan 4, 2022
In reply to @ubikings "Let's hope the needful is done soonest" + (show)
@ubikings

Let's hope the needful is done soonest

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Hello @ubikings, Welcome to Connect. It sounds like you also may be sufferring from neuropathy and looking for something that helps. Are you able to share a little more about what brought you to Connect?

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Dave Hayward | @davehayward1 | Jan 5, 2022
In reply to @janstar61 "I actually contacted the owner of the company that was to be testing that drug. I..." + (show)
@janstar61

I actually contacted the owner of the company that was to be testing that drug. I am not sure they were able to get the funds to complete the studies. My doctor said he has not heard of anything that cures neuropathy as of yet.

Jump to this post

Just a suggestion:
Pirenzipine is described as a "muscarinic antagonist”. Perhaps there are other meds in this class that are worth looking into as well

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