I have had a low iron level for years and take Vitron C, which has helped get my ferritin levels out of the danger zone. However, as far as weakness/depleted energy, I have found that taking a healthy amount of vitamin B12 helps tremendously! I also exercise a ton more than I ever have in my life, and that has been a huge help as well. I have increased my protein and believe that is also helpful. Hope your wife finds a solution to this debilitating problem.