Thank you, John. I checked out the discussion on central sensitization. When i found Mayo Connect, I recall that I was searching for information on obesity and osteoarthritis- trying to find some inspiration/ motivation to lose weight to help my knee. The post about neuropathy caught my attention because my attacks of peripheral neuropathy have been so difficult, maddening and caused me to lose much sleep. I mentioned Alpha Lipoic Acid supplements which have been amazing, but I have also made lifestyle changes. I have reduced hours at work, changed my diet to mostly vegetarian/no wheat or sugar, resolved some stressful relationships, began swimming 3-4x week. I am grateful to have found a wonderful neurologist.