Estradiol is a naturally occurring estrogen hormone while Premarin is a drug that consists of a mixture of estrogen.
As mentioned before, I switched from Premarin to Estradiol in March 2021 (at age 74 after taking Premarin for 43 years) and I have not experienced any changes of any kind. I have read a few articles indicating that, based upon when Estradiol was started, it has some indication of preserving brain function (memory, etc). I seem to have a little more energy over these past several months but can't say if it was a result of changing estrogen as I have always had a very high level of energy. I would be interested in knowing what your decision is and any result you may experience.
Donna 393