I am 74 and have taken Premarin since age 31 (43+ years), which means that I have never had any chemistry change within my system. There are 3 chemistry issues within the body: thyroid, pancreas, and estrogen. The medical community balances the thyroid and pancreas (diabetes), but not estrogen. My doctor retired and I found only ONE doctor who was willing to prescribe an Estradiol patch for the next 12 months because she is retiring at that time. I have not seen any difference with the patch. I now find that there is an enormous problem for all of us who have taken estrogen for the long term, and the result of that problem is the lack of data and/or studies to guide or advise us as to what medical consequences, if any, we may suffer if we stop taking it after more than 30-50 years. An equally important problem is what options are there if we want to continue taking estrogen because we experienced a lifetime of excellent health? Taking Premarin for more than 43 years has prevented heart disease for me since it was a result of hereditary factors. At age 43, my cholesterol was almost 500 and at age 58, with the same cholesterol level, my triglycerides were 672. I have battled those scores for more than 40+ years and they are now in the normal ranges but I still have to monitor them. My bone density (June 2021) came in with a Z-score for the lumbar spine of 0.3, neck -0.1, and hip .04, and those scores are compared to the bone mass of a 30 year old adult, the lower the number, the greater loss of bone. I have been medically diagnosed as "frozen in time" to a young/middle-aged women because of long term use of Premarin and statins. I had a normal mammogram in June 2021. The problems are "(1) what to do if I/we can't continue getting the prescription for estrogen, and (2) if hospitalization won't continue coverage." I believe going public with our "specific group of long term estrogen users" is the only way to bring these problems to the attention of the medical and pharmaceutical communities. They must work on finding a healthy solution, including producing data and studies, for our "long term estrogen group," a group that no one acknowledges or even knows exists.