@alexgoldman2, several members of my family have disappearing white matter in the Cerebellum, sometimes called by other names. Nearly all of the family have various forms of Multiple Myeloma. I and a couple others have Gelsolin and FKTN. Others have LECT2, Apolipoprotein, full onset MM, etc. But nearly all have the Cerebellum issues, along with other stuff. One sister and her daughter have died in their 6th decade of "unknown causes". Another is near death, and my son is approaching it. Make sure that you are genetically tested for these and similar, especially concerning the heart and brain. The quickest and easiest test is the ECG, showing the difference between the Left Ventricle Systolic and Diastolic, compared to the Right Ventricle Systolic and Diastolic. Also the presence of Long QRT segment. Also things like organomegaly, cardiomegaly, tongue (glossal) megally, many cancers (my surgeries have been for thyroid, larynx, gall bladder, melanoma, etc. My retinas have a dystrophy, which seems common to cerebellum atrophy. Anyway, also get a good clinic-grade full genome analysis to lock it it. At 3-4 hundred dollars, its a bargain.