Absolutely no idea what is causing many symptoms. Had a CT scan two years ago after an accident - mild concussion. No sign of anything irregular with pituitary gland. CT scan was done beginning of May as they are trying to figure out why I am so tired, pain in legs, hands and muscle weakness. They found that my sella around pituitary was empty and vastly different than two years ago. Many blood tests performed and waiting for urine results. My symptoms are major fatigue, getting "turned around" easily, pain and stiffness in hands, pain in feet when getting out of bed in morning, horrible itchy hands (usually pads on palm) and feet periodically (usually at night), can't find words, sometimes in a fog. I don't drink alcohol or soda, eat well - no fast food or preservative filled, dizziness but unlike vertigo. I take 15 mg. of adderall daily, 25 mg of pristiq daily, 10 mg of clonazepam in morning and 20 mg. at night and one Vitamin B-12. I just turned 58, 5'2, 120 lbs, very small boned and had a partial hysterectomy at 37 leaving one ovary. She's definitely dead! Any advise would be great. My hands bother me the most. It almost feels like my skin is going to split open when I try to make a tight fist (particular on right side). I'm so tired of hearing "we do not know what to do." I don't want anything wrong but I sure would like to know how to fix whatever is going on and get some answers. Thanks all.