Oh my gosh, I know exactly how your husband is feeling. I knew that I felt this way a long time ago and I did what I could to bury those feelings or avoid situations that caused me to feel like running . It came to full cycle 3 yrs ago when I couldn't leave the house or talk to anyone outside. I've been taking alprazolam (xanax) to help. But, it doesn't always work. Mine stemmed from my past and abuse. Sometimes I think some people , normally of high intelligence, are born this way. My own father at the age of 55, became sick with it and eventually tried suicide. Please be patient with your husband and try to see if you can get him to talk with a Dr. Even if it's telehealth. It doesn't get better until you figure out what's causing it and medication . Thx