Hi @rogereddy, welcome to the Lung Health group.

Regenerative medicine (stem cell therapy) for COPD is still in the research phase. Do use caution about promises made by some clinics.

To help people learn more about the proven therapies and the promise of developing therapies, Mayo Clinic offers a free telephone consult service. When you call the consult service, they will tell you about the availability of approved stem cell therapy at Mayo Clinic and elsewhere, and for what conditions. You can learn more about the Consult Service here http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-services/regenerative-medicine-consult-service.
Or call 1-844-276-2003 to speak with one of our experts.

You can read more in this discussion:
– Stem Cells / Regeneration https://connect.mayoclinic.org/discussion/stem-cells-regeneration/

You mentioned that you are open to considering the Zephyr valve. Is this a treatment option available to you?