Thank you so much for your response. Actually, the patient is myself and I feel that I have had symptoms for many years that have been misdiagnosed. Symptoms: knees that gave out as a child into young adulthood; constant need to crack knuckles, neck, and back from childhood on: double jointed, esp in hands; severe insomnia most of my life; scoliosis;; gi problems including reflux and fecal incontinence; urinary incontinence; RLS for past 18 years;stretchy loose skin over back of hands, diffuse migrating joint pain and back pain; recent pancreatic insufficiency; orthostatic hypotension. Also type 2 diabetes. I have been sent from specialist to specialist including rheumatologists with no satisfaction. I am now depressed and ready to give up. No real pain relief. By the way, I am 68 years of age. I worry about passing genetic disease to my daughters and grandchildren. My mom has severe hypnosis and my sister's have scleroderma and crohn's disease. Thank you so much even for the opportunity to share my frustration. Thanks for listening.