Hello,

I am also decreasing my seroquel but have never had a manic episode so not sure how this information and the risks would feel different for you. I am feeling a lot better now that I am on week 3 of 75 mg if seroquel (down from 100) but the withdrawals at first were brutal. I felt like I couldn’t stop talking, was very anxious, and had racing thoughts. I saw a naturopath about it and these were her suggestions:

“In reviewing strategies to help with Seroquel wean I came across an
alternate wean schedule:

Once under 100mg decrease dose by 10mg every 2 weeks.
Under 20 decrease by 5mg for 1-2 weeks.
At 5mg dose every other day for 2 weeks and then every 3 days for 2
weeks. Then off.

This schedule would make your wean go slower, but it may mean less side
effects when you go down each level. It's possible to see if the
compounding pharmacy can make the smaller doses. This may be something
to consider.

I also found that any strong stimulants for the adrenals are
contraindicated during Seroquel wean. This would be adrenal glandular,
and even some ginsengs. Instead, it is best to focus on supportive
nutrients and calming herbs.
Vitamin C and B complex (especially B5 + B6) are cornerstones. You'd aim
to get vitamin C 2000mg (divided doses, 1000mg twice per day) and
consider a good quality B Complex that provides 100mg B6 and 300mg B5
(the AOR Advanced B Complex has these amounts in 3 caps, you may be able
to find it at the health food store, order it online, or let me know and
I can put it in with our next AOR order).

We also have a remedy called Passifloraplex that is used to help with
calming. You can take drops daily or just dose as needed if you feel
anxiety or overstimulation.”

I’m not sure how to get that wean cycle- my pills only come in 25 mg but I will speak to my pharmacist and psychiatrist to see what the other options are so that I can follow this wean schedule. I am also going to try a B-complex and upping my vitamin C to her recommended dose.

Hopefully this helps us both decrease our dosages now that we are under 100 mg.

Take care

@budapest00 Welcome to Mayo Clinic Connect, a place to give and get support.

I'm wondering if you ever found what you are looking for? It's important to always ween off of medications under a provider's/doctor'/s supervision. This is especially true when a bi-polar diagnosis is part of the situation. May I ask if you have a trusted provider or someone that can help you receive adequate care?