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Restless legs syndrome (RLS) and mirtazapine

Depression & Anxiety | Last Active: Oct 25, 2023 | Replies (66)

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Hi All, I landed here in my quest for information about the correlation between mirtazapine and RLS. The latter had never been an issue for me before starting the mirtazapine. I have been on my current regimine for some time now (over a year) and it hasn't subsided.
For me, taking the med earlier is counter-productive to my sleep. I need to hit that "window" of 20-30 minutes between taking the med and going to bed for optimal sleep.
I wanted to share something that has been helping: I have one of those wedge pillows, and I recently started sleeping with my legs elevated on the wedge...it's really helping! I'm sure there is a solid physiological explanation but I haven't researched it, I'm just relieved to have something that helps.
I do walk regularly. I have a large breed dog (Cane Corso) who needs a lot of exercise, so she makes me get out for an hour or two every day.
Another thing I'm going to try is a weighted blanket. I have one, just have it stowed away somewhere. I love it for other reasons (really does feel like a hug, helps with my anxiety), it's just that my current living situation is temporary and cramped so I have been operating with the basics.
Lastly, my doc is starting me on vistaril PRN today. I have been advised that I can take it every night, once a month, or any frequency in between without concomitant effects.
Just wanted to share my experiences as I continue to find resolution for this most annoying issue, and learn from this community.

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Replies to "Hi All, I landed here in my quest for information about the correlation between mirtazapine and..."

Hello @vhn, Welcome to Mayo Clinic Connect. Thank you for sharing your experience with RLS and mirtazapine and tips with what helps you. I also sleep with my legs slightly elevated to help with swelling and circulation problems (lymphedema). Here's some information on the topic - What Are the Benefits of Elevating Your Legs? - https://www.healthline.com/health/elevating-legs

Do you mind sharing what you were searching for when you found Connect?