Can Gabapentin make neuropathy pain worse?

Posted by cwallen9 @cwallen9, Apr 16, 2019

I started getting peripheral neuropathy pain about nine months ago in my feet and hands right after I received a cervical steroid injection. I started taking gabapentin about 7 months ago. I have gradually increased my dose from 100 mg a day to 1500 mg. I can't say that it has decreased my pain at all. In fact, my pain has gotten steadily worse. I was just wondering if it is possible that gabapentin can sometimes make neuropathy pain worse. My EMG and biopsy results are negative for short fiber neuropathy so far.

Interested in more discussions like this? Go to the Neuropathy Support Group.

@lacy2

hello @cwallen9 .... oh never hear of Zonegran before.... may i ask how long you have been on it ... be nice if you could get some pain relief soon. Good that you have not had bad side effects yet... have you had any side effects even minor? Am afraid I always go on line to check new meds out but sometimes this means then I am too afraid to take them... especially if they list eye problems as a possible side effect as I already have Glaucoma so don't think I should try these... but Clonazepam I do take has side effects tookto but at least I get some sleep. Sometimes we have not much choice... Best of luck. Take care, J.

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Just for about 5 days. It is probably not the full dose either. You know how it is - it can weeks or months to find out if it helps. I will try to keep everyone posted - especially if it helps.

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@jakedduck1

@dorisena
“I feel victorious when I can make a difference.”
You make a difference in many people's lives.
You helped me and my cousin who has diabetes. THANK YOU!!!
Jake

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Jake, you are welcome. Come to dinner anytime. I live alone and would love the company. Dorisena

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@dorisena

Jake, you are welcome. Come to dinner anytime. I live alone and would love the company. Dorisena

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@dorisena
Don't suppose you live in California?
Jake

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@salsa

Obviously every case is different, but in mine I take 2700 mg a day. Alot I know, but before it my episodes would last an hour or so, it was brutal. Now, I still get my episodes but they last maybe 10 minutes to 15 minutes max. I don't like being on it, but my neurologist at the Mayo assures me it is ok. I always looking for other options, but no luck so far. Maybe an increase would help, as for me I would say taking it has not increased my pain, but has been a help in reducing episode length. Good luck to you, I hope you find some answers.

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I’m new here as well I was diagnosed with SFN 1 year ago I take 4500 mg of gabapentin a day and 300 mg of Quespatine 1/2 in the morning 1/2 at night with 40 mg of Paxil at night for insomnia because of the pain . I still only get about 4 hours sleep . also for aniexty daily 1 mg 2 times a day Clonazepam . I had surgery December 23rd with a permanent Boston Scientific Tens unit all of this With no no help... as with others I’ve read Everything thinks your crazy . Going crazy the pain never shuts off know matter what you do or take . I don’t feel hot or cold sensations / I’ve even tried the bed stinging technique for Neuropathy was stung 10 on one leg and and 10 on the other 3 different sessions with a neperapin in waiting incase I had a reaction. Didn’t even know I was getting stung I asked when he was going to get started and I’d already been stung he said the stingers our still in your leg pumping the venom . Seems there is no help
Just live with it I just can’t swallow that .

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@milesdaviskindofblue

I’m new here as well I was diagnosed with SFN 1 year ago I take 4500 mg of gabapentin a day and 300 mg of Quespatine 1/2 in the morning 1/2 at night with 40 mg of Paxil at night for insomnia because of the pain . I still only get about 4 hours sleep . also for aniexty daily 1 mg 2 times a day Clonazepam . I had surgery December 23rd with a permanent Boston Scientific Tens unit all of this With no no help... as with others I’ve read Everything thinks your crazy . Going crazy the pain never shuts off know matter what you do or take . I don’t feel hot or cold sensations / I’ve even tried the bed stinging technique for Neuropathy was stung 10 on one leg and and 10 on the other 3 different sessions with a neperapin in waiting incase I had a reaction. Didn’t even know I was getting stung I asked when he was going to get started and I’d already been stung he said the stingers our still in your leg pumping the venom . Seems there is no help
Just live with it I just can’t swallow that .

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Hello @milesdaviskindofblue, Welcome to Mayo Clinic Connect. Sorry to hear you haven't found much relief for the Neuropathy pain. There is another discussion you may want to read through to learn what other members have shared helps them.

Member Neuropathy Journey Stories: What's Yours?:
https://connect.mayoclinic.org/discussion/member-neuoropathy-journey-stories-whats-yours/

Also, you might find this article on Treatment Options and Pain Management posted by @steeldove helpful.
https://connect.mayoclinic.org/discussion/use-new-article-about-treating-peripheral-neuropathy/
What's the worst of your neuropathy symptoms if you had to rate them?

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Thanks for insight I’m at my end of answers more questions then a appealing
Fix . I’ve seen 4 Neurologist the I e I’m currently seeing has been helpful in answering but says no cure just have to deal with it . That’s easier said then done when your a prisoner in your own home

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I am new and not sure how to post a question so I am sorry if I am doing this incorrectly. I just started on Gabapentin 300 mg at night 15 days ago and it has allowed me to sleep helped lessen my widespread whole body dysesthesia (face and every part of my body that started suddenly in Jan 2021) somewhat but had to still put CBD cream or combination of Sarna Original or Sarna Sensitive over most of my body during day. Doctor added 100 mg Gabapentin at 8am which I took this morning and now my pain is completely different and worse. Burning is a combination of an intense burn and prickling. Has anyone else had this when first going on additional doses and if so does it get any better?

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@marenew

I am new and not sure how to post a question so I am sorry if I am doing this incorrectly. I just started on Gabapentin 300 mg at night 15 days ago and it has allowed me to sleep helped lessen my widespread whole body dysesthesia (face and every part of my body that started suddenly in Jan 2021) somewhat but had to still put CBD cream or combination of Sarna Original or Sarna Sensitive over most of my body during day. Doctor added 100 mg Gabapentin at 8am which I took this morning and now my pain is completely different and worse. Burning is a combination of an intense burn and prickling. Has anyone else had this when first going on additional doses and if so does it get any better?

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Hello @marenew - Welcome to Connect. I have no experience with dysesthesia but I'm hoping other members will be able to answer your question. @nanna and @dablues have mentioned dysesthesia in other discussions and may be able to offer a suggestion.

Have you discussed the worsening of your symptoms with your doctor to see if they might have a suggestion?

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@johnbishop

Hello @marenew - Welcome to Connect. I have no experience with dysesthesia but I'm hoping other members will be able to answer your question. @nanna and @dablues have mentioned dysesthesia in other discussions and may be able to offer a suggestion.

Have you discussed the worsening of your symptoms with your doctor to see if they might have a suggestion?

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As this is the first day of taking the additional dosage I have not called doctor yet. My nerve burning started as neuropathy of the feet and progressed up the legs and then over face and down the front of my body back to the feet!!! All tests negative by neurologist and no underlying medical or auto immune cause. I could deal with the feet neuropathy but the whole body nerve burning is reason why gabapentin was ordered.

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@johnbishop

Hello @marenew - Welcome to Connect. I have no experience with dysesthesia but I'm hoping other members will be able to answer your question. @nanna and @dablues have mentioned dysesthesia in other discussions and may be able to offer a suggestion.

Have you discussed the worsening of your symptoms with your doctor to see if they might have a suggestion?

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There is no outward appearance so doctors don't seem too concerned but it gets very uncomfortable especially around the ribs ...when it tightens up it feels like someone is sitting on my chest and I feel like I cannot breath and when it takes over the whole left side of my body I get unbalanced. It never leaves but some days are worse than others. The only offering of help is gabipentin and if I take it at night it causes me to not be able to think straight the next day. I have read you could get surgery and cut the nerves which I would be up for around my ribs.

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