Hi, @karent57 - welcome to Mayo Clinic Connect. I'm sorry to hear your husband was a nightmare and downright scary with taking high doses of prednisone, yet he had to take it as an absolute last resort for treatment. Glad his doctors kept a very close watch on him.

I have to take prednisone myself from time to time for a 5-day course due to asthma that gets exacerbated beyond what my normal medication can handle. I know that it is not my family's favorite when I have to take it. I can tell you from my own experience that it's a bit rough for the patient taking it, as sleep is really hard to come by, and it's very difficult for me to hold in my emotions. It's like everything is magnified and your reactivity is, too.

I'm hoping that @suefarar1 will return and share her experiences with prednisone, and I'd also like to invite @tinkerbell @eileen14 @seanlroop @kimh @aland and @cubs0816, who have mentioned this medication, to share their stories with prednisone.

@karent57 - will you share a bit more about your husband's medical situation that prompted his treatment with high-dose prednisone?