I understand what I think chemo brain is. I was 59 when I had rectal cancer and was treated with Xeloda along with radiation and surgery. It has been two years and the last oncology follow up was good. Looking forward to the 5 year mark when things are supposed to be positive that cancer is not coming back. Chemo brain I believe also changed my personality for quite a while. My temper was unbelievably short and things that I used to be able to figure out and quickly solve became frustratingly difficult. I had trouble focusing and concentrating on complicated tasks. I do think that as time goes on it is getting a little better at least for me. Not much was said at any time as chemo brain being a potential side effect and truthfully I don't know if it would have made much difference in my choice of treatment. Once I came to grips with the fact I had a life threatening situation in my body that would grow if I didn't take action I sort of went on autopilot and only focused on what I had to do from hour to hour to get through the treatment. But chemo brain is definitely real. I force myself to do simple puzzles that are based on subjects I like. In a way maybe like Alzheimer treatment. It seems to have helped me anyway. I also get much more sleep than I used to and not much keeps me from getting it. Listening to my body if you will, as I am still building on the stamina I lost.