Hi, @thomason. I don't have nearly as much knowledge as some of the wonderfully, sharing and giving people here who have helped me immensely since I was diagnosed with bronchiectasis in October but one thing that has helped me with inhalers and nebulizing is making sure that I am only breathing in through my nose. My first CT scan showed that my esophagus "sits funny," whatever that means and I have always had sinus issues so was in the habit of breathing through my mouth (also a terrible snoring problem since childhood). The first month of trying out inhalers sent me to the ER three times because I was breathing in through my mouth and it was swelling up my larynx so I was not getting air through the top of my throat and not getting the medicine into my tubes and lungs. I was fighting mad because I felt like everything the doctors were giving me was making me worse and was feeling pretty helpless. This one small change, that I really have to concentrate on, has made a world of difference in my life. Wishing you all the best and praying for some answers and relief for you. ~Echo