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mjay (@mjay)

At Home DNA Tests

Breast Cancer | Last Active: Feb 12, 2021 | Replies (10)

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Hi Colleen,
Thanks for your inquiry. I think you’re understanding correctly. Long story short: I had BC, but BRCA gene tests were negative. My mother and her two sisters had breast cancer but they found no genetic link with my BC. I recently took an at home DNA test and there were several BC genetic indicators not related to the BRCA genes, which are the most recognized BC genes. By researching these additional gene SNPs, they point to some issues with a MTHFR polymorphism, as well as some other factors such as detoxification issues related to methionine, etc. So after gaining this knowledge, I’m wondering if others have focused on correcting these other non-BRCA genetic factors. There are functional naturopathic type doctors, not traditional medicine, that would study these genetic factors and help guide you to address the issues. So, for example, the MTHFR SNP means I don’t absorb Vitamin Bs fully and that could be a factor in BC, although not as direct as the BRCA genes, so that can easily be addressed by making sure I get the most bioavailable form of Vitamin B and eating dark leafy greens. I hope that helps clarify where my thinking is going. There are many natural ways to address cancer that are related to a healthy diet and/or supplements that may actually reduce the risk of cancer returning depending on what your deficiencies are so that’s where my thinking lies. I hope that helps clarify!

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Replies to "Hi Colleen, Thanks for your inquiry. I think you’re understanding correctly. Long story short: I had..."

@mjay, thanks for taking the time to explain. I get your query now. Unfortunately, I don't have answers. Genetics and cancer is a relatively new field and so much to explore.

SNPs of genes associated with breast cancer can be used as a potential tool for improving cancer diagnosis and treatment planning. You can read more here (medical journal): http://journal.waocp.org/article_27798_4f54566a1f0205b00300b100f6e33d37.pdf

While not specific to single nucleotide polymorphisms (SNPs), you might be interested in this Mayo Expert Q&A
– Cancer-Fighting Foods https://connect.mayoclinic.org/webinar/cancer-fighting-foods/