mtt, I'm glad you are doing well. My understanding is the lower dosage works as well. I asked my Onc to lower my dosage to 100 just to see if it would boost my blood counts to more normal levels, but he won't. He says he uses the highest tolerable dosage and since I have no side-effects from the Ibrance he prefers to stick with 125. I lead a fairly slow life-style (baby sit grandkids) stay-at-home mom of 1 last "at-home" son (17 and a senior in H.S.) ....I'm 59 and was an older mom. I hike and that's where the aches start up. Mainly from the bone mets in my upper femurs and lesions on my sacrum and ilium. I've had to shorten the hikes or I get pretty stiff, from babying the legs I think. All in all I can't complain as things could be worse.
Nice talking with you.
Peggie