I happened across your post from October and hope you are doing well. I've been on Ibrance with Letrozole since June 2019 and never had any side effects from the Ibrance (no nausea). I've only recently (Jan 2021) had my neutrophils drop to the bottom of the "average" range, not the range they need to be concerned with yet. I've also always been on 125 mg which they can lower if you do have side effects and I've heard it is just as effective. The letrozole (estrogen blocker) caused me thinning hair and some joint aches but the aches have gotten less as time has gone by.
Peggie