@junec. I have met bc to the bones. I have now gone thru all three of the AI’s, as I have had severe reactions to each of the meds to the point when on exemestane had me feel like I was dying. There have been recent articles about ibrance on the mews and there seems to be such a slight benefit it may or may not be worth taking. If it makes you feel worse and only gives you 3-4 more months of pain and agony is it worth it? I don’t mean to sound pessimistic but having this disease is hard enough but the horrific side effects I had were worse. Have decided to take a natural route, but this is not for everyone.