@nrivers I have been reading and thinking about PN for many years. The first recollection I have of that feeling was about 60 years ago while I was playing football for U of Puget Sound. Since then I have fought that sensation all over my body at different times. Feet (even individual toes), calves, thighs, hips, skin around my trunk, shoulders, head, tongue, hands, arms, eye sockets, scalp. All over at different times and different groups. And I have tried every med my 50 docs have suggested, from aspirin to opium to marijuana. The Mary Jane caused me to wreck our car in our own driveway. So far, only one substance has been regularly successful, and I think I know why. Small doses (1/4 Teaspoon) in a glass of warm water has regularly worked. Actually, I have had some success with warfarin. I think it is because PN is a blood disorder, not just nerve. The nerve myelin and actin sheathes around the nerve cells block the needed blood contents from getting into the cells in the proper order of things. But these two blood thinners, especially the turmeric, enable the blood elements to get through the actin and myelin sheathes and supply the needs of the nerve cells. But both these blood thinners are dangerous if one takes too much. Now, there are two caveats. First, I am not a medical doctor, so I have to get whatever knowledge I can get from wherever I can take it. And, I could be way wrong. This is only my personal experience of 60 years. I have a number of genetic issues which may be causing this. Diabetes 2, Gelsolin (Finnish Amyloidosis), and FKTN (Fukutin Limb Girdle Muscular Dystrophy #4. But I use Turmeric once or twice every month, it seems. And it works. Selah.