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kyc117 (@kyc117)

Heat Intolerance: Symptom of Neuropathy?

Neuropathy | Last Active: Sep 17, 2020 | Replies (83)

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@margaret10 Hi Margaret, I read your earlier post that said you also have had neuropathy in your feet for 18 years. Just curious when your Addison's developed? My brother has had Addison's for about 25 years or more, not sure he knows why he got it, I have never heard him talk about that aspect. I am wondering if your Addison's might have developed from the neuropathy, any idea? Thanks, Hank

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Replies to "@margaret10 Hi Margaret, I read your earlier post that said you also have had neuropathy in..."

Hi Hank,

My Addison's is a result of the surgical removal of my left adrenal gland that had a tumor (pheochromocytoma) when I was 9 years old. The tumor was caused by a mutation in my SDHB gene which I likely inherited from one of my parents. My remaining adrenal is only able to partially compensate for the missing one, resulting in decreased adrenal hormones. My Addison's was not diagnosed until age 42.

Addison's can be caused by a genetic mutation, tuberculosis, an autoimmune disease (the most common cause), etc., but I am not aware that it is caused by neuropathy. As you know, neuropathy can be caused by hundreds of different disorders. In my case, I believe it's caused by marginal cortisol deficiency resulting in an overactive immune system and resulting inflammation in my feet.

Your brother could, if he hasn't already, see an endocrinologist and ask for tests that measure his adrenal hormone levels, and if they're low, get a prescription for what he's missing. He could also get an anti-nuclear antibody test to find out if it's autoimmune. Best of luck to him.