After cleaning our all tramadol, codeine, tylenal I went through hell for weeks . 2 drug therapies are routinely recommended at that point if chronic migraine is primary diagnosis —. Topirimate or amytriptylene. Tried the first with bad reaction and titrated amytriptylene starting at 10mg working up weekly to 80 mg. Had a period of a few weeks with no headaches. But then they returned but much milder and not daily. I take no painkillers. The theory was a hope I would revert to the severe migraines of my youth which could then be treated with current therapies. Have not had a severe classic migraine . . . Yet. I am happy where I am now way less daily pain .