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ER+ Mutated no longer using Estrogen: ESR1 And PIK3CA Mutations
Breast Cancer | Last Active: May 6, 2022 | Replies (13)Comment receiving replies
Hi @trivia, I moved your recent post together with your earlier question about ESR1 mutation. I thought it might be helpful to keep the conversation together and hopefully find others with the same mutation. From what I've read studies are showing that fulvestrant (Faslodex) stimulates ESR1 protein degradation and is superior to aromatase inhibitors in ESR1-mutated ER+ tumors.
@dianamiracle and @ja5747 have also taken or are taking Faslodex. @rraw started this discussion and is also taking Faslodex
- HER2 positive & HER2 negative: I have both at the same time https://connect.mayoclinic.org/discussion/her2-positive-her2-negative/
Trivia, I can certainly understand your hesitation about chemo if you don't have progression at the moment. Does your oncologist suggest chemo to prevent progression or as a future option if progression is detected?
Replies to "Hi @trivia, I moved your recent post together with your earlier question about ESR1 mutation. I..."
Hello All,
Yes I guess I did start this conversation about being HER2 positive and HER2 negative both at the same time . Yes I have the PIK3CA mutation as well. I am currently taking Faslodex and Herceptin for HER2 + it appears to be working in that the tumors we knew were HER2 + appear to be stable. The HER2- is a bit more stubborn. I have taken a number of things including Piqray and it’s been unsuccessful. We moved to Halavan in mid September. I get PET scan results back on Thursday to see how well it’s working. The CA15-3 (tumor marker) tests did show significant drops for a few months but the end of December started to slowly tick back up..... hence the new PET scan. Here’s another twist one of my tumors is Barc positive..... I am not..... but the tumor is. I am a walking mess but I feel just fine. I have about 2 days of exhaustion following the Halavan infusion but otherwise nothing much to speak of. My bloodwork indicates everything is functioning properly (kidneys, liver etc) My already thin hair has thinned a bit more since I started Halavan but I look good bald🤗😂Thanks for letting me share!
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Yes, my oncologist is ok with the Faslodex alone as long as there is no progression. He did recommend chemo (Xeloda) if it comes back or progresses.