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ER+ Mutated no longer using Estrogen: ESR1 And PIK3CA Mutations

Breast Cancer | Last Active: May 6, 2022 | Replies (13)
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@trivia

Hi Everyone, I'm Stage 4 Breast Cancer with mets in liver. The mets were radiated in August of 2020. I've had the standard chemo, mastectomy, lymph node ressection and radiation on the breast area in 2019.
I wondered if anyone who has the same mutations and if they are taking Faslodex alone? Doesn't ESRI 1 mutation mean that the Estrogen receptor has also mutated? My Oncologist hasn't seen any progression or new spots since the Radiation of the liver lesions, even though there is also the Pik3 mutation which is usually dosed with Picqray. I really don't want chemo if I can help it (which it seems like I am successful so far). So, just wondered about the ESRI 1 mutation mostly.

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Replies to "Hi Everyone, I'm Stage 4 Breast Cancer with mets in liver. The mets were radiated in..."
Colleen Young, Connect Director | @colleenyoung | Dec 21, 2020

Hi @trivia, I moved your recent post together with your earlier question about ESR1 mutation. I thought it might be helpful to keep the conversation together and hopefully find others with the same mutation. From what I've read studies are showing that fulvestrant (Faslodex) stimulates ESR1 protein degradation and is superior to aromatase inhibitors in ESR1-mutated ER+ tumors.

@dianamiracle and @ja5747 have also taken or are taking Faslodex. @rraw started this discussion and is also taking Faslodex
- HER2 positive & HER2 negative: I have both at the same time https://connect.mayoclinic.org/discussion/her2-positive-her2-negative/

Trivia, I can certainly understand your hesitation about chemo if you don't have progression at the moment. Does your oncologist suggest chemo to prevent progression or as a future option if progression is detected?

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