@jolinda Thanks for the info and congrats on a successful PKD surgery. In terms of the estradiol/estrogen, none of my medical professionals here seemed to know about that. I was on HRT for three years before learning from others I should not be taking it. I stopped it on my own July 2019. Went to Mayo in October and the PKD/PLD specialists were shocked that my family practice doc, OB/GYN, nephrologist and liver specialist had no clue. Last month I did do a telemedicine appointment with an OB/GYN at Mayo because after six years of not having a period (am not on birth control) and lab work indicating I am post menopause, I have started bleeding again. In my discussion I did mention to the Mayo OB/GYN about my PKD/PLD and the estrogen issue. She wanted to put me on Premarin cream, noting due to how it is administered, it should not be an issue compared to an oral pill. She was concerned about bone health. I have another call with her at the end of the month to go over new lab work she had me do here locally.