Hello Jeffrap, I too have osteoarthritis and severe osteoporosis (daily Prednisone); several fractures over the years. Left knee is bone on bone, ortho wants to replace but not yet. So I thought the knee pain was from that but it's skin pain not it bone pain. It really is neuropathy Sxs. I 'm glad you asked the question whether or not neuropathy can exacerbate the osteoarthritis. I hope we get some answers. My Neurologist had no comment on that. Take care, Sunnyflower