It is important for Connect members to know a lot more about the reversing agent suggested by @darbybauer for serious bleeding when it is related to the anticoagulants Eliquis and Xarelto. The reversing agent is Andexxa, and it was indeed approved by the FDA in 2018. But Andexxa is not a pill to take with lunch. In the FDA news release announcing approval of Andexxa, you may find the following expert statement: "Andexxa's rapid reversal of the anticoagulating effects of rivaroxaban and apixaban will help clinicians treat life-threatening bleeds, where every minute counts."

Note the reference to the use by "clinicians treat(ing) life-threatening bleeds, where every minute counts." The crucial implications of that statement are 1) Andexxa is for intravenous application not an at-home antidote; 2) it is recommended for use by "clinicians" in a highly specialized treatment environment; 3) its use is recommended when a bleed is life-threatening. Be careful and be sure of the presence of a qualified medical professional when an antidote is needed for a bleed while taking Eliquis or Xarelto. Martin

Jump to this post