I have pretty severe muscle and joint pain, particularly in my back, neck, and hands. My legs get very stiff when I get up from sitting and lying down. It’s worse after walking, standing for more than an hour or so, and sitting at my computer. I have read all about Tacrolimus and had assumed it was that. Since I’m five months out and it is continuing to get worse my doctor wants to eliminate other possible causes. So, since I’m quite underweight I’m getting a bone density scan to check if I have osteoporosis. Next may be a neurologist, as I also have worsening tremors and numbness in my leg.

Re: pain and sleep, have you tried melatonin? Chamomile tea, kava, and similar herbal sleep remedies can interfere with Tacrolimus, so best to avoid. I take 1 or 2, 100 mg caps (the lowest dose) of gabapentin at night. It doesn’t help with pain other than nerve related (so it helps with liver pain), but it is relaxing and really helps me to sleep. It isn’t metabolized by the liver, so doesn’t interfere with Tacrolimus. I hope you can at least find sleep soon...it’s so important for healing and wellbeing.