@gphetteplace Hi I do get a sharp pain once in a while in my lower calfs, if I stand on it it goes away in just a few seconds. Very strange but it works.
Blessings
Dana

Hi, I came into this discussion a little late. Hopefully by now you’ve gotten some relief from the bone and joint pain...and some sleep! While I I didn’t have a liver transplant, I did receive a bone marrow transplant. We share many of the same anti rejection meds. Tacrolimus being one of them. That medication, along with a few others, are known to deplete our bodies of magnesium fairly quickly. I have to take supplements daily to maintain a normal level. A low level can produce similar symptoms along with myriad other issues. Do you have routine blood draws frequently? If so, maybe mention to your physician to add a mag level to your next labs. The level should be 1.7 or higher. Best of luck to you! Lori

I have pretty severe muscle and joint pain, particularly in my back, neck, and hands. My legs get very stiff when I get up from sitting and lying down. It’s worse after walking, standing for more than an hour or so, and sitting at my computer. I have read all about Tacrolimus and had assumed it was that. Since I’m five months out and it is continuing to get worse my doctor wants to eliminate other possible causes. So, since I’m quite underweight I’m getting a bone density scan to check if I have osteoporosis. Next may be a neurologist, as I also have worsening tremors and numbness in my leg.

Re: pain and sleep, have you tried melatonin? Chamomile tea, kava, and similar herbal sleep remedies can interfere with Tacrolimus, so best to avoid. I take 1 or 2, 100 mg caps (the lowest dose) of gabapentin at night. It doesn’t help with pain other than nerve related (so it helps with liver pain), but it is relaxing and really helps me to sleep. It isn’t metabolized by the liver, so doesn’t interfere with Tacrolimus. I hope you can at least find sleep soon...it’s so important for healing and wellbeing.