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Transplant anti-rejection medications. What's your advice?

Transplants | Last Active: Apr 1 4:58am | Replies (320)

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@jerrynord

I have heard this before but yesterday I got a message from CVS pharmacy with my Tacrolimus prescription. It said do not drink grapefruit juice or eat grapefruit while taking Tacrolimus. Has anyone heard this?

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Replies to "I have heard this before but yesterday I got a message from CVS pharmacy with my..."

@jerrynord yes, there are a multitude of medications that do not interact well with grapefruit. Also, with tacrolimus you need to avoid pomegranates as well.

@jerrynord
There are several things that are dangerous to eat/drink if you are taking Tacrolimus! Grapefruit, grapefruit juice, pomegranates, pomegranate juice, Fresca soda and Seville oranges are for sure on the NEVER consume list. These foods and beverages are known to interfere with Tacrolimus and change the potency of the medication in unpredictable ways which leaves you venerable to organ rejection. I'm glad you've chosen a pharmacy that adds warnings to your meds. Did they have any other instructions that could be shared with the group to keep us healthy?

@jerrynord, Thanks for the reminder!

I find it helpful if I re-read the papers that I get with my immunosuppressant medications. Mayo Specialty Pharmacy always includes printed information about my meds in my delivery orders. I get my other medications locally - and if I have an afterhour medicationi from a chain pharmacy I never get the papers. When I asked "Why" I was told that nobody reads them anyway! Hmmm? My independent local pharmacy always includes the paperwork!

For more information:
- Immunosuppression: Watching For and Managing Side Effects
"Some medications and foods may change how immunosuppressant drugs work. Before you use any other medications, talk to your nurse transplant coordinator or transplant pharmacist so they can make sure the new medication is safe to use with your transplant medications. You should do this for both prescription and over-the-counter medications. Over-the-counter medications would include vitamins, supplements, and herbal products. Some common foods and beverages that may affect how your body uses your immunosuppressant drugs include grapefruit or grapefruit juice, sodas with grapefruit juice in them (ie. Squirt™, Fresca™, or Sundrop™), Pomegranate and pomegranate juice (ie. Pom™), Seville oranges, also called Spanish, sour or bitter oranges, and more than 6 clementines per day. These foods should be avoided if you are taking a tacrolimus or cyclosporine product , sirolimus, or everolimus." https://connect.mayoclinic.org/page/transplant/newsfeed-post/immunosuppression-watching-for-and-managing-side-effects/

-Transplant Medications 101: Q&A
Foods to avoid, drug interactions, best time of day to take medications and what to do if I forget a dose.
https://connect.mayoclinic.org/page/transplant/newsfeed-post/transplant-medications-101-qa/

Does anybody else get notices with their meds? Do you read it? What have you learned or been reminded of by reviewing the information?

Yes, they told me that after my transplant. Also nothing with pomegranate or Seville oranges.