Hi Rosemary, Congratulations on your transplantversary! And thank you for all of your thoughtful responses on Mayo Connect. What would we do without you? My heart transplant was 3 years and nearly three months ago. Was placed on tacrolimus and cellcept and prednisone. Like you, I have an autoimmune disease - sarcoidosis - which caused the cardiomyopathy in my heart. Still on 5 mg on prednisone; it can cause bruising on my forearms - I do a lot of gardening and am a real klutz - but my doctor wants to keep the sarcoid at bay. I don't think I'll ever be off of it. The tacrolimus affected my kidney function - and I had measurable hair loss - and I was switched to sirolimus after 8 months post transplant. My hair now is thicker than ever before in my life. I have gained weight - nearly 20 pounds - I must say I am enjoying life and food. But I'm active and now that the weather is in the 90s in Arizona, I'm swimming every day and doing water aerobics. My skin is fragile in certain areas and I've had to have cauterization to stave off infection. But I'm not complaining. Every day is a gift!