how was your husband diagnosed with RA? I was first diagnosed with it 31 years ago. The bloodwork did not show evidence from the rheumatoid factor. i had joint pain everywhere. the big thing that showed up in the bloodwork was the sed rate (ESR). my sed rate was well beyond 20 (o-20 is normal). Sed rate is a measure of inflamatory/pain one might feel. I was started on methrotrexate and my liver enzymes went off scale. In y worst days my sed rate was up to 150. i had gone thru all the biologic modifiers with somevery severe results. when i was on kineret, i had kidney failure and gained 43lbs and was hospitalized for 1 week till they could get my kidneys back to normal. when i was on humira i had torn retinas in both eyes (at different times), which had to be repaired. after that i told my PCP i will regulate my RA with prednisone and oxycodone . to day i stll do. I have had 2 knee replacements on my right knee,1 knee replacement on my left knee, i hip replacement on left hip. this is how i reacted to the RA drugs. My bodyis very sensitive to medicine.... i am 68 years old and will need my left hip and left knee replaced (16 yeas old and 17 years old respectively. i would be curious to know what medicine your husband is on. i aslo had dry corneas inboth eyes from the RA which requires Restasis in both eyes daily. RA is a progressive degenerative disease . I also have stenosis in the lower back (L4-L5), which requires cortinsone shots in the back. I have stenosis in my neck which can't be operated on. when a person is on pain relievers (NSAIDS), such as ibuprofen, remember to take it with food, or your stomach will get very bad. Being an RA patient i cannot donate blood, due to my still active RA. I cannot take any NSAIDS due to previous kidney failure and my stomach cannot stand theheartburn(even after stomach fundoplication). Being on prednisone and having RA means i am immuno supressed, which with this corvid-19 virus i have to wear a mask where i go... good luck and god bless to you and your husband and happy easter!..... kozlo52