My pharmacist was very helpful in scheduling my Big 3. I take every Monday, Wednesday and Friday - 2 Rifampin first thing in the morning ( no food ), then 3 1/2 Ethambutol at lunch and then 1 Azithramycin at dinner. Hope this helps and I absolutely hope you can tolerate your meds. Best of luck to you !

@n4seth The schedule for taking the Big 3 has to be what is best for you and how you can tolerate them. What Toni1132 said is probably quite good. The only thing I would add is if you need a probiotic you should probably take that first in the morning on an empty stomach. Rifampin can be one hour before or two hours after a meal with a full glass of water. Ethambutol and azithromycin can be taken after breakfast with a full glass of water eight hours before or four hours after your daily multivitamin. Your vitamins and probiotics should be separated from the antibiotics by at least four hours. NOW foods probiotic-10 or Ultra Jarro- Dophilus (50 billion per capsule) are good ones. I follow a schedule a former mentor used during her MAC journey. irene5