Sorry so late in replying to your post. I don’t get time to check regularly sometimes. For what it’s worth, I’ve been on the “three” daily for 6 months. Think my year is just starting as just had first negative sputum. I was worried about GI effects and started taking Kyolic (there is a lot of research on aged garlic extract and the gut biome) two (600 mg) twice a day along with 600 mg NAC (Lung support as it’s a precursor to glutathione) twice a day as well. My gut has been fine and it even got rid of food allergies I have suffered with for years. I also take a probiotic when I think about it at night. I take Kyolic when I get up in the morning, then antibiotics and NAC with my blend of hot cocoa, coffee and collagen. I had a little nausea at first, and took something for that, but never not one day of cramping or diarrhea. Gas yes, but I’m not complaining. I started to feel better in general after about 6-8 weeks on the antibiotics. I hope this helps. It’s good to have a variety in info available. Don’t give up, it will get better!