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COVID-19 and Transplant Patients

Transplants | Last Active: Mar 6, 2021 | Replies (459)

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@sueinmn

Hi Dana & @jolinda -
I too would be cautious about finding out the safety for transplant patients before taking the vaccine - I wonder if anyone in the Mayo transplant department knows if there have been transplant recipients included in any trial?
But my question is - since the purpose of all the vaccines like flu, shingles and pneumonia is to provoke an immune response, is the Covid-19 vaccine any different?
Sue

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Replies to "Hi Dana & @jolinda - I too would be cautious about finding out the safety for..."

@sueinmn- Can I jump in here? This vaccine is different in that it introduces, for the first time ever on humans, the mRNA-based vaccine.(the molecule which tells cells what to build) genetic material called mRNA inside a special coating so other proteins won't attack it. Once produced within the body, the antigen is recognized by the immune system, preparing it to fight the real thing. mRNA can most easily be described as instructions for the cell on how to make a piece of the “spike protein” that is unique to SARS-CoV-2. Since only part of the protein is made, it does not do any harm to the person vaccinated but it is antigenic. https://www.cdc.gov/vaccines/covid-19/hcp/mrna-vaccine-basics.html

DNA based vaccines use a weakened or synthetic material vs the mRNA which have the actual live virus. This is needed because SARS-CoV-2 is an unknown virus to our bodies and an immune reaction needs to be activated in order to make this happen.

Since I am not a science major I hopefully haven't mess this explanation up too badly!

Here is more information
http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/
https://www.phgfoundation.org/briefing/rna-vaccines

I just received s message back from my transplant Care Team on covid-19 vaccine for transplant patients. There is currently no vaccine approved for transplant patients. Mayo will notify me/ keep me updated. On information regarding vaccination for transplant patients.