I also use this for nighttime pain in a knee replacement, as I am not able to take Ibuprofen like meds. It is quite effective. Some insurance company's have to have extra justification for it from your doctor, which if they would put the reason that you can’t use ibuprofen, would avoid delays. Does anyone else with a knee replacement have no pain during the day, but bad pain at night when trying to move that leg. Seems odd to me.