A lot of the sex drive (libido) has to do with the hormone shots you have in connection with and before treatment ...even surgery.. the Lupron shot initially is to shrink the prostate.. so it can be targeted more easily... I had only one shot.. but the effects hang around for a year... some men get a series of shots .. 1 every 4-6 months... for a couple years... so you and your doctor ... even an oncologist must have a talk...