Well, im an odd duck as i have developed ibs with years of cic. I started the dosing slowly as i was afraid of sude effects too. Im now up to 2mg. My headaches got worse for awhile. I would say ive had a fair amount of bloating, gas. I thought at a few weeks ago it started working, i had movement without help. But now my gut is being so unfriendly, i cant tell what its going to do. And im not sure if thats the motegrity or ibs or mixture of all this crap. I see gastroenterologist soon, but im sure ill stay on it for awhile as Ive tried and failed with all other meds. I hope you figure out if its worth a shot. Hope it helps if you do. Im looking at more opinions before surgery. Good luck and let me know how you do.