If you haven't already had your Appleby procedure, the best advice I can give if find a doc who has performed it many times successfully. Same goes for Whipple. My wife had Appleby after chemo and radiation. Top hospital and top pancan surgeon in the country. Surgery was a complete success with all pathology negative. Recovery however has been extremely difficult. Removing 60% of the pancreas, gaul bladder, spleen, adrenal gland and 23 lymph nodes at once is extraordinarily hard on the body. My wife wasnt overweight and has lost 20% of her body weight due to pain, loss of appetite and chronic diarrhea. Good luck with your surgery and recovery.