Hi Hank, my doctor told me about making LDN from a 50 mg naltrexone tablet and then I looked it up on the internet for more details. Measure out 50 milliliters of DISTILLED water and pour it into a small bottle. I use a small brown bottle that a nerve supplement I used to take came in. You also need a bottle cap that you can insert a syringe into. I use a 1 milliliter syringe, but a 5 milliliter one might be better for larger doses. Once the distilled water is in the bottle put in a 50 mg tablet of naltrexone. Place the bottle in the refrigerator. From what I read it takes 2 hours for the tablet to fully dissolve. Once dissolved the full bottle contains 50 mg of naltrexone in 50 milliliters. Therefore, 1 ml equals 1 mg of naltrexone. The bottle must be kept in the refrigerator at all times. You must also shake the bottle well before you take each dose. I believe everything I just stated is accurate, but it’s best to look this up if you want to make LDN yourself. Your doctor will advise you concerning this as well. Good luck!