@rwinney I have pain at nite also. Not severe, but not good. I have a few inhales of marijuana. Very light inhales. I hate being stoned. That and the LDN seem to do the trick for the evening. I do not remember; do you use marijuana? It does seem to be ok at night in terms of not feeling too much pain. If the LDN worked for you, it might be even enough. You never know. To clarify, you are saying that the night LDN dose you would take, would interfere with the Hydro from working? The LDN would close the receptor sights, and the hydro could no longer attach to them. I am sleepy. I hope I am making sense. Have marijuana in me as I write. I hope I am making some sense!!!!! Lori