As far as I know, ET with a positive JAK2 mutation normally suggests you have a high platelet count. I have MDS and MPN. On the MPN side I have ET and MF. Since there is no cure for MPN diseases or MDS diseases absent a stem cell transplant your oncologist or hematologist will treat your symptoms. I had a very high platelet count so I'm on hydroxyurea which is the standard treatment to reduce one's platelet count. I was diagnosed after a bone marrow aspiration, biopsy and a molecular panel. The molecular panel indicates multiple gene mutations and that was the conclusive scientific evidence the Leukemua doctors at Sloan needed to make a definitive diagnosis and a treatment plan. Sloan said there is a 30% chance of mutation to full blown Leukemia at which time they'll discuss a stem cell transplant. The good news is there is 70% chance of no mutation to Leukemia, so just live your best life. Good luck.