Thank you for that valuable information. I will be interested to see how that works out. I know that they have been coupling benfotiamine with vitamin B12 and rather large doses generally in Europe and have had some pretty good success. A number of years ago I was suffering in my toes in the bottom of my feet behind my toes my brother told me one of the stewardesses on his plane had a problem with it also she used benfotiamine and if she skipped those she really felt it he suggested I try it. I did and I have been on it ever since. Pass on the good word I believe it works! God bless and peace to everyone