Oops, I didn't read this response. 18 months on prednisone seems like a very long time to be prescribed. Not sure what you were diagnosed with to warrant that long of treatment. Perhaps an integrative medical professional could offer some ideas. I am seeing one next week that has some experience in treating people that have had after effects of taking antibiotics like me. My surgeon who put me on the antiobiotic treatment said that it could take weeks to come out of the funk I am in with central nervous system issues. Cipro and Flagyl were what I was on and both can do this. I just wish that I was told this before being given these.