1. < Neuropathy

Scientific research and scholarly papers on Small Fiber Neuropathy

Posted by burningfeetinphoenix @burningfeetinphoenix, Sep 28, 2019

@burningfeetinphoenix...here. I started a new discussion as in looking through the discussions, I could find no discussion on research, clinical trials, published papers etc, on SFN. I thought this might be a new forum for discussion. I'll let the moderators decide where to put it. I have trouble finding posts as I am new to using this forum... only recently being diagnosed with SFN which I would say was "acute SNF" as I never had a symptom of it until one day in Early April 2019 my feet started burning. I've seen a while back a question came in on types of PN and types of SFN. I finally found the dissertation on SFN that defines its different kinds and symptoms with acronyms. Well, I found it and here it is:

"Small Fiber Neuropathy: Disease Classification Beyond Pain and Burning"
Todd D Levine 2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912271/
Interesting that Dr. Levine is with Phoenix Neurological Associates where I am going on October 11th after a several month wait. They are involved in several clinical trials for idiopathic SFN. I am anxious to finally be seeing a neurologist having gotten nowhere with the podiatrist. I am also anxious to talk to them about their research and the clinical trials. Still hopeful! Pam

Interested in more discussions like this? Go to the Neuropathy Support Group.

Mentor
John, Volunteer Mentor | @johnbishop | Sep 28, 2019

Here are some research links that I had previously posted on our Minnesota Neuropathy Association (http://neuropathy-mn.org/). There are also many newer peripheral neuropathy research on the Foundation for Peripheral Neuropathy website at https://www.foundationforpn.org/research/,

Repairing the Neural Highway By David Holmes, Nature Magazine, December 13, 2017:
-- https://www.nature.com/articles/d41586-017-07551-8

Spinal-Cord Injury: Spurring Regrowth By David Holmes, Nature Magazine, December 13, 2017:
-- https://www.nature.com/articles/d41586-017-07550-9

Nerve wrapping nanofiber mesh promoting regeneration National Institute for Materials Science (NIMS), February 28, 2017:
-- https://www.sciencedaily.com/releases/2017/02/170228223753.htm

New Research may pave the way for peripheral nerve damage repair Researchers from Plymouth University are the first to identify the role of a bodily protein in peripheral nerve self-repair, Journal of Cell Biology, 30 January 2017:
-- https://www.plymouth.ac.uk/news/new-research-may-pave-the-way-for-peripheral-nerve-damage-repair

UCSD “Blocking Neuron Signaling Pathway May Lead to New Treatments For Peripheral Neuropathy.” NeuroscienceNews, 17 January 2017:
-- https://neurosciencenews.com/peripheral-neuropathy-signaling-pathway-5958/

Study finds a key to nerve regeneration Source: University of Wisconsin-Madison ScienceDaily September 16, 2016:
-- https://www.sciencedaily.com/releases/2016/09/160916132053.htm

Research Tools that I have also found useful.

About Herbs, Botanicals & Other Products -- Memorial Sloan Kettering Cancer Center’s About Herbs database, a tool for the public as well as healthcare professionals, can help you figure out the value of using common herbs and other dietary supplements.
-- https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine/herbs

Be an informed consumer -- NIH’s National Center for Complementary and Integrative Health (NCCIH) which offers guidance about integrative health and how to evaluate it. -- https://nccih.nih.gov/health/decisions

FDA’s Don’t Be Fooled by Health Fraud Scams -- https://www.fda.gov/consumers/consumer-updates/dont-be-fooled-health-fraud-scams

Google Scholar -- https://scholar.google.com/

REPLY
1 reply
burningfeetinphoenix | @burningfeetinphoenix | Sep 28, 2019

Looks like some great late night reading material when I cannot sleep due to my burning feet! Thanks John... I am @burningfeetinphoenix

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Mentor
Rachel, Volunteer Mentor | @rwinney | Sep 28, 2019

Hi Pam

My Neurologist is Dr. Charles E. Argoff who is the 3rd listed author who collabotated on this book with Dr. Todd Levine in 2017. It's fantastic that you will be meeting with Dr. Levine soon. I meet with Dr. Argoff Wed of this week. Ready with my research and list of questions and concerns!

I will be curious to hear how you make out. I'll post my findings and next plan of pain management, and know you will do the same.

It's pretty cool that I'm in New York and you're in Arizona and there is this connection. Good luck!!
Rachel
REPLY
1 reply
Mentor
Rachel, Volunteer Mentor | @rwinney | Sep 28, 2019
In reply to @johnbishop "Here are some research links that I had previously posted on our Minnesota Neuropathy Association (http://neuropathy-mn.org/)...." + (show)
@johnbishop

Here are some research links that I had previously posted on our Minnesota Neuropathy Association (http://neuropathy-mn.org/). There are also many newer peripheral neuropathy research on the Foundation for Peripheral Neuropathy website at https://www.foundationforpn.org/research/,

Repairing the Neural Highway By David Holmes, Nature Magazine, December 13, 2017:
-- https://www.nature.com/articles/d41586-017-07551-8

Spinal-Cord Injury: Spurring Regrowth By David Holmes, Nature Magazine, December 13, 2017:
-- https://www.nature.com/articles/d41586-017-07550-9

Nerve wrapping nanofiber mesh promoting regeneration National Institute for Materials Science (NIMS), February 28, 2017:
-- https://www.sciencedaily.com/releases/2017/02/170228223753.htm

New Research may pave the way for peripheral nerve damage repair Researchers from Plymouth University are the first to identify the role of a bodily protein in peripheral nerve self-repair, Journal of Cell Biology, 30 January 2017:
-- https://www.plymouth.ac.uk/news/new-research-may-pave-the-way-for-peripheral-nerve-damage-repair

UCSD “Blocking Neuron Signaling Pathway May Lead to New Treatments For Peripheral Neuropathy.” NeuroscienceNews, 17 January 2017:
-- https://neurosciencenews.com/peripheral-neuropathy-signaling-pathway-5958/

Study finds a key to nerve regeneration Source: University of Wisconsin-Madison ScienceDaily September 16, 2016:
-- https://www.sciencedaily.com/releases/2016/09/160916132053.htm

Research Tools that I have also found useful.

About Herbs, Botanicals & Other Products -- Memorial Sloan Kettering Cancer Center’s About Herbs database, a tool for the public as well as healthcare professionals, can help you figure out the value of using common herbs and other dietary supplements.
-- https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine/herbs

Be an informed consumer -- NIH’s National Center for Complementary and Integrative Health (NCCIH) which offers guidance about integrative health and how to evaluate it. -- https://nccih.nih.gov/health/decisions

FDA’s Don’t Be Fooled by Health Fraud Scams -- https://www.fda.gov/consumers/consumer-updates/dont-be-fooled-health-fraud-scams

Google Scholar -- https://scholar.google.com/

Jump to this post

John-
You are a powerhouse!

REPLY
sunny2 | @sunny2 | Sep 28, 2019
In reply to @rwinney "Hi Pam My Neurologist is Dr. Charles E. Argoff who is the 3rd listed author who..." + (show)
@rwinney

Hi Pam

My Neurologist is Dr. Charles E. Argoff who is the 3rd listed author who collabotated on this book with Dr. Todd Levine in 2017. It's fantastic that you will be meeting with Dr. Levine soon. I meet with Dr. Argoff Wed of this week. Ready with my research and list of questions and concerns!

I will be curious to hear how you make out. I'll post my findings and next plan of pain management, and know you will do the same.

It's pretty cool that I'm in New York and you're in Arizona and there is this connection. Good luck!!
Rachel

Jump to this post

@rwinney Rachel, I see you are a patient of Dr.Argoff. I have started seeing a neurologist who is also in the Albany Med neurology group. I will be interested to see how you make out at your appointment and I’ll have to get this book for sure. This may help when I see my doctor in October. Hoping you have a productive appointment next week!

REPLY
1 reply
Mentor
Rachel, Volunteer Mentor | @rwinney | Sep 28, 2019
In reply to @sunny2 "@rwinney Rachel, I see you are a patient of Dr.Argoff. I have started seeing a neurologist..." + (show)
@sunny2

@rwinney Rachel, I see you are a patient of Dr.Argoff. I have started seeing a neurologist who is also in the Albany Med neurology group. I will be interested to see how you make out at your appointment and I’ll have to get this book for sure. This may help when I see my doctor in October. Hoping you have a productive appointment next week!

Jump to this post

Thank you. Will keep you posted.

REPLY
burningfeetinphoenix | @burningfeetinphoenix | Oct 7, 2019

I came across this book as I get automatic emails for various subjects from several academic journal sites I found it on Amazon. It is expensive but I am willing to tackle it when I am up at night with my burning feet...it is:

"Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration" April 2019 Sung-Tsang Hsieh et al. It should be a challenge!

One can read the free sample in the Amazon Cloud or download to tablet or Kindle. I dis but have not read yet. Preparing for my appointment with the Neurologist this Friday. Lots to do!

Pam

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burningfeetinphoenix | @burningfeetinphoenix | Oct 8, 2019

Here is some middle of the night reading for those, like me, who are trying to figure out why my feet are on fire and cannot sleep through the night. Interesting take on heat sensation...Got that book I mentioned yesterday and it is a keeper! Very technical but covers all bases...Pam

Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects
E P Wilder‐Smith W‐Y Ong 1 Y Guo A W‐L Chow
First published: 09 October 2007 https://doi.org/10.1111/j.1365-2559.2007.02851.x Cited by: 27
E. P. Wilder‐Smith, Division of Neurology, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore. e‐mail: mdcwse@nus.edu.sg

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timsdeece | @timsdeece | Nov 13, 2019

Just read the paper mentioned in the OP. Not very heartwarming. It always just boilds down to anticonvulsants and antidepressants if you're idiopathic 🙁

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