Hi, my name is Carlavan and I to have ET with JAK2 mutation, my initial complaint to my primary was always extreme tiredness, headaches, and itchy dry skin. I too, thought thyroid. But after repeated blood workup & over time, she noticed elevated platelets and ordered a referral to a hemotologist who did the extreme blood testing at a lab in Texas. The diagnosis of ET and mutation was given and I was put on Hydroxya and 81mg aspirin. It is a chemo pill that destroys platelets and brings my counts within a normal range under 400,000. I am still tired, but I go great until about 7:00 at night. Skin is still a problem and the occasional headache. But all and all, I look around me each day and know it could be much worse. Good luck to you and I would seek a second opinion. I would want treatment if I were you.