FWpoole, my first go around, I did 3 RCHOP, ever 3 weeks, followed by 21 radiation treatments. I’ve read in Cure magazine that chewing on ice chips during your chemo can help prevent mouth sores. I did the post treatment with L lysine and glutamate powder and my mouth sores were fairly tolerable. Talk to your doctor about magic mouthwash, too if you develop sores.