@beatitnow I have gotten my voice back. I’ve been on Arikayce 9 months. I think effectiveness depends on underlying conditions and if you keep being reinfected. I went to National Jewish in CO in July. I found out I am a carrier for the genetic disorder Alpha 1 Antitrypsen. This causes your bronchial cilia to essentially be paralyzed, which makes it difficult to clear infections. I am anticipating having this until I die. I’m only 47, so doing daily airway clearance and boiling my drinking water and ordering a special shower filter, the only one proven to eliminate MAC. Happy to answer any questions you have!